Description
The vaccine contains purified diphtheria and tetanus toxoids and inactivated B. pertussis organisms. The toxoids are adsorbed onto 3 mg / ml aluminum phosphate. Thimerosal 0.1 mg/ml is used as a preservative. The potency of the vaccine per single human dose is at least 4 IU for pertussis, 30 IU for diphtheria and for tetanus 60 IU.
Indication
Active immunization against diphtheria, tetanus, and pertussis.
Composition
Each ml contains :
Purified diphtheria toxoid 40 Lf
Purified tetanus toxoid 15 Lf
Inactivated B pertussis 24 OU
Aluminum phosphate 3 mg
Thimerosal 0.1 mg
Dosage and Administration
The vaccine vial should be thoroughly shaken before use to homogenize the suspension.
The vaccine should be injected intramuscularly or deep subcutaneously.
The anterolateral aspect of the upper thigh is the preferred site of injection
(An injection into a child's buttocks may cause injury to the sciatic nerve and is not recommended).
It must not be injected into the skin as this may give rise to local reaction. One dose is 0.5 ml.
A sterile syringe and a sterile needle should be used for each injection.
In countries where pertussis is of particular threat to young infants, DTP immunization should be started as soon as possible
with the first dose given as early as 6 weeks, and two subsequent doses given at 4 weeks intervals.
DTP vaccine can be given safely and effectively at the same time as BCG, Measles and Polio vaccines (OPV and IPV),
Hepatitis B, Hib and Yellow Fever vaccine.
Side Effects
Some temporary swelling, tenderness and redness at the site of injection together with fever, occur in large proportion of cases. Occasionally severe reactions of high fever, irritability and screaming develop within 24 hours of administration. Very rare neurological complications allegedly due to the pertussis component, have been observed but are rare in comparison to those observed in the course of disease.
Contraindications
There are few contraindications to the first dose of DTP. Abnormal cerebral signs in the newborn period or the other serious neurological abnormality are contraindications to the pertussis component, DT should be given instead. A second or subsequent dose of DTP should not be given to a child who has suffered a severe reactions to the previous dose. The pertussis component should be omitted, and only DT given for the remainder of the course. Individual infected with human immunodeficiency virus (HIV), both asymptomatic and symptomatic, should be immunized with DTP vaccine according to standard schedules.
Storage and Expiry
Keep at temperature between 2° - 8°C. DO NOT FREEZE.
Expiry date : 2 years
Presentation
Vials of 10 doses
