Pentabio (DTP-HB-Hib) Vaccines
Pentabio is a DTP-HB-Hib combination vaccine in forms of homogenous suspension containing: Diphtheria toxoid and pure tetanus, inactive Pertussis bacteria (whooping cough), non-infectious pure Hepatitis B surface antigen (HBsAg) and non-infectious HiB component which is a conjugation result between polysaccharide subunit of Haomophilus influenza type B and tetanus toxoid.
HBsAg protein is produced through yeast DNA recombination. The polysaccharide subunit is originally from Hib bacteria grown in a particular media, which is then purified through several steps of ultrafiltration. Vaccine is sequestered in aluminum phosphate. Thimerosal acts as preserving agent.
Vaccine potential per dosage is less that 4IU for pertussis, 30 IU for diphtheria, 60 IU for tetanus (determined in rat) or 40 IU determined in guinea pig, 10mcg HBsAg and 10 mcg Hib.
Vaccines are used for the prevention of diphtheria, tetanus, pertussis (whooping cough), hepatitis B, and Haemophilus influenzae type b infection simultaneously.