BIO – Td Vaccine

Bio Td is a white suspension in glass vial, containing tetanus and diphtheria toxoid with a low diphtheria component which has been puri ed and adsorbed in aluminum phosphate. One dosage of vaccine contains potential of less than 30 IU of diphtheria toxoid and less than 40 IU of tetanus toxoid. This vaccines is used as active immunization to diphtheria and tetanus in adult and children starting 7 years old. This vaccine is a suspension for injection.

COMPOSITION

Each dosage of 0.5 mL contains

  • Puri ed Tetanus toxoid 7.5 Lf
  • Puri ed Diphtheria toxoid 2 Lf 
  • Aluminum phosphate 1.5 mg
  • Thimerosal 0.05 mg 

Indication: Repeating tetanus and diphthe- ria immunization for an individual starts at the age of 7 years old.

POSOLOGY

Recommended to give 1 dosage of vaccine. Administering Bio Td to substitute vaccines containing Tetanus and Diphtheria has to be based on o cial recommendation considering the low dosage of toxoid diphtheria in this vaccine. Applying Bio Td for vaccination for primary vaccination and pregnant woman has not been evaluated. Can be administered together with measles, polio (OPV and IPV), hepatitis B, yellow fever and vitamin A supplement.

SIDE EFFECTS

Clinical trial reported pain in injection location (20-30%) and ever (4.7%).

CONTRADICTIONS

Second dosage and its subsequent should not be administered to individuals su ering

Each dosage of 0.5 mL contains • Puri ed Tetanus toxoid
• Puri ed Diphtheria toxoid • Aluminum phosphate

7.5 Lf 2 Lf 1.5 mg 0.05 mg Indication: Repeating tetanus and diphthe- ria immunization for an individual starts at

• Thimerosal
the age of 7 years old.

MODE OF ACTIONS

Triggers tetanus and diphtheria antibody formation 

heavy reaction to previous dosage.

Immune system de ciency

HIV infected individuals either symptomatic or asymptomatic should be vaccinated with Bio Td based on set schedule.

DRUG INTERACTIONS

  • Vaccine should be shaken before administered to homogenized suspension

  • Before administering vaccine, images on the Vaccine Vial Monitor should be followed

    Notes:
    Advisor committee on Immunization Practices (ACIP) has recommended sequestered Tetanus and Diphtheria toxoid for pregnant women. Vaccine Td may be administered as primary immunization for individuals starting age of 7 years old whom had contradictions to DTP vaccine. Based on ACIP, two dosage of sequestered Td 0.5ml with reduced dosage diphtheria in adults with minimum interval of 4-8 weeks. Administering 3rd (third) dosage is at least 6 month after 2nd (second) dosage.

    STORAGE

    Stored between +20C to 80C, protect for sunlight. DO NOT FREEZE

    EXPIRED:

    2 Years

PACKAGING

Box @10 vials (0.5mL/1 dosage); Reg. No
• Inner part of the square is lighter than the outer circle. If the expired period hasn’t

end, Vaccine CAN be used.
•By time, inner part of the square has

changed color but it’s still lighter than the outer circle. If the expired period hasn’t end, Vaccine CAN be used.

• ENDING PERIOD
The inner part of square is equal to the outer circle. DO NOT USE VACCINE

• OVER THE ENDING PERIOD
The inner part of the square is darker than the outer circle. DO NOT USE VACCINE

Vaccine vial monitor is a part of the vaccine Bio Td ethics in forms of a red dot which is time-temperature sensitive and functions as indicator of accumulated vial (vaccine) heat exposure. It is an indication for users on vaccine validity.

Vaccine Vial monitor is easy to read. Center it to the square in the middle of the circle. The color will gradually change. As long as the color of the square is lighter than the circle then vaccine can still be used. If the square color is equal to or darker than the circle, vaccine should be immediately be disposed. Must be accompanied with doctor’s prescription