Vaksin Poliomyelitis Oral Monovalen Tipe 1

DESCRIPTION
mOPV1 vaccine is a light yellow to pink liquid in glass vial, contains suspension of type 1 attenuated polio virus (Sabin strain).

COMPOSITION
Each dose (2 drops = 0.1 mL) contains :
Active ingredients:
• Attenuated Polio virus (Sabin  strain) type 1 ≥ 106.0 CCID50*
Excipients:
• Erythromycin not more than 2 mcg
• Kanamycin not more than 10 mcg
• Sucrose 35 % v/v (as stabilizer)

* CCID50 = Cell Culture Infective Dose 50

INDICATION
Active immunization against poliomyelitis type 1 in response to outbreak condition.

MECHANISM OF ACTION
Stimulates the body to produce antibody against Polio type 1.

POSOLOGY

  • mOPV 1 must only be administered orally.
  • Two drops are delivered directly into the mouth from the multidose vial by dropper.
  • Care should be taken not to contaminate a multidose dropper with saliva.

SIDE EFFECTS
In the vast majority of cases there are no side effects. Very rarely, there may be vac- cine-associated paralysis (one case per 3 million doses administered). Persons in close contact with a recently vaccinated child may very rarely be at risk of vaccine- associated paralytic poliomyelitis.

CONTRAINDICATION
In case of diarrhea, the dose received will not be counted as part of the immunization schedule and it should be repeated after recovery.

  • Patient with leukaemia and disgam- maglobulinemia.
  • Children with acute infection along  with fever.
  • Children with immunological defi- ciency.
  • Children with immunosuppressive  treatment.

DRUG INTERACTION
Immunosupressive medicines.

WARNING & PRECAUTION

  • Must only be administered orally.
  • Simultaneous vaccination with other live vaccine should be administer sep- arately.
  • See information on vaccine adminis- tration

STORAGE

  • Vaccine is potent if stored at not more than -20°C until the expiry date indi- cated on the label of the vial.
  • It can be stored for up to six months between +2°C to +8°C.
  • Expiry date 2 years.

The use of Opened Multi-Dose Vial Vaccine
Multi-dose vials of mOPV1 from which one or more doses of vaccine have been removed during an immunization ses- sion may be used in subsequent immu- nization session for up to a maximum of 4 weeks, provided that all of required conditions are met.

PRESENTATION
Box:
10 vials @ 1 mL (10 doses)
10 vials @ 2 mL (20 doses)
50 vials @ 2 mL (20 doses)