Oral Poliomyelitis Vaccine


Oral Polio Vaccine (OPV) is a trivalent vaccine. It is a reddish yellow liquid, which is packed in glass vial. It contains suspensions of types 1, 2 and 3 attenuated Polio viruses (Sabin strains). This vaccine is a suspension to be administered orally with dropper.


Each dose (2 drops = 0.1 mL) contains:
Active ingredients:
Attenuated Polio virus (Sabin strain)

  • type 1 ≥ 106.0 CCID50*
  • type 2 ≥ 105.0 CCID50 
  • type 3 ≥ 105.8 CCID50

Excipients :

• Erythromycin not more than 2 mcg
• Kanamycin not more than 10 mcg
• Sucrose (stabilizer) 35 % v/v

* CCID50 = Cell Culture Infective Dose 50


Active immunization against poliomyelitis.


Stimulates  the  body  to produce  antibody against Poliomyelitis.


  • OPV must only be administered orally. Two drops are delivered directly into the mouth from the multidose vial by dropper.
  • Care should be taken not to contaminate a multi dose dropper with saliva.
  • Infants should receive at least 3 doses of OPV with intervals of 4 weeks, at 2 months of age.
  • Booster is given 1 to 3 years afterward; 1 dose.


  • In  the  vast  majority  of  cases  there  are no side effects. Very rarely, there may be vaccine associated paralysis (one case per 1 million doses administered).
  • Persons in close contact with a recenly vaccinated child may very rarely be at risk of vaccine associated paralytic poliomyelitis (one case per 1,400,000 until one case per 3,400,000 doses).
  • Guillain Barré Syndrome.


  • In  case of diarrhea, the dose received will not be counted as part of the im- munization schedule  and it should be repeated after recovery.
  • Leukaemia   and  disgammaglobulinemia patients.
  • Children   with   acute   infection   along with fever.
  • Children with immunological deficiency.
  • Children    with    immunosuppressive treatment.


Immunosuppressive medicines.


  • Must only be administered orally
  • Simultaneous vaccination with another live vaccine should be administered separately


  • Vaccine is potent if stored at not more than  -20°C until the  expiry date  indi- cated on the label of the vial.
  • It  can  be  stored  for  up  to  six  months between +2°C to +8°C.
  • Expiry date 2 years.

The use of Opened Multi-Dose Vial Vaccine

Multi-dose vials of OPV from which one or more doses of vaccine have been removed during  an  immunization  session  may  be used  in subsequent immunization  session for up to a maximum of 4 weeks, provided that all of required conditions are met. 

• Box : 10 vials @ 1 mL (10 doses)
• Box : 10 vials @ 2 mL (20 doses)
• Box : 50 vials @ 2 mL (20 doses)