Immunization on Special Clinical Circumstances

  • Persons recently received immunoglobulin

Immunoglobulin may inhibit the immune response to vaccines, the duration of inhibition may vary with the indication for immunoglobulin and specific product; suggested interval is 3 months after Immunoglobulin administration.

  • Premature Infants

Premature infants and infants with low birth weight, should be immunized at the usual chronological age in most cases. For premature infants with birth weight of less than 1 kg, Hepatitis B immunization should be delayed until the weight is 2 kg or more, or until approximately 2 months of age, except if the mother is HBsAg positive. 

  • Immunocompromized patients

Immunocompromized may occur as primary immune-suppressive treatment or underlying diseases. Live vaccines generally are contraindicated.

Warning and Precaution on Vaccine Administration

  • The vaccine vial should be shaken to homogenize the liquid
  • Sterile syringe must be used for each injection
  • Before use, information on Vaccine Vial Monitor (VVM) should be followed
  • For vaccines to be administered intramuscularly, care must be taken to avoid local reaction, if not administered appropriately. The anterolateral aspect of the upper thigh is the preferred site of injection. An injection into a child’s buttocks may cause injury to the sciatic nerve and is not recommended. For the child and adult, it should be injected to deltoid muscle.
  • It must be given with precaution to individuals with history of allergic and febrile illness. Adrenaline 1 : 1000 should always be available to immediate anaphylactic treatment.