The commitment of green industry is implemented in all business lines as one of the policies of the corporate. Every poduct produced by the Company refers to the green criteria which initiated by the raw material selection, production process, formulation, filling, packaging to final products. All of this scheme has implemented green process. The innovation of Bio Farma is the green industry implementation strategy with ISO: 14001 standard along with the other several innovations, such as waste management hierarchy principle on the output of company’s activities within the 4R : Reduce, Reuse, Recycle and Recovery process and also the implementation of Reuse, Recycle and also Recovery Modern innovation technology on wastewater. The development of a sustainable innovation is a must in order to be able to produce various biotechnology-based products altogether with the green commitment which will lead Bio Farma towards sustainable green industry.